The aim of MODERN is to understand the processes governing the interactions of eNPs with biological systems and their associated mechanisms of toxicity for nanosafety assessment. Nanotoxicity data of well characterized eNPs will be obtained from within the consortium, other NMP projects, the literature and public data repositories. Targeted experiments will also be carried out to validate the nanostructure-property relationships and nano-bio interactions established with the application of advanced computational methods.

The following objectives will be pursued to model nanotoxicity as a function of the intrinsic molecular and physicochemical properties, and to guide safe-by-design strategies:

  • To apply computational methods and models for the characterization of the structural and physicochemical properties leading to quantitative nanostructure-property relationships (QNPRs) and safe-by-design strategies for eNPs;
  • to develop in silico quantitative nanostructure-activity relationships (QNAR) of biological activity of eNPs in the organism and in the environment;
  • to analyze signatures of key molecular-level responses (e.g., genes, proteins and pathways) caused by eNPs at environmental exposure levels (low concentrations) that can lead to long-term effects; and
  • to establish a categorization and hazard ranking framework for eNPs based on structural similarity principles and in the analysis of their toxicological profiles. The resulting nano(eco)toxicity models will contribute to diminishing the need for animal testing.